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Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis
- Source :
- Micromachines, Volume 11, Issue 10, Micromachines, Vol 11, Iss 944, p 944 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of Technology and at Harvard Medical School&rsquo<br />s teaching hospital, the Massachusetts Eye and Ear&mdash<br />and later at the startup company Bionic Eye Technologies, by some of the same personnel. These efforts culminated in the fabrication and assembly of 256+ channel visual prosthesis devices having flexible multi-electrode arrays that were successfully implanted sub-retinally in mini-pig animal models as part of our pre-clinical testing program. We report on the processing of the flexible multi-layered, planar and penetrating high-density electrode arrays, surgical tools for sub-retinal implantation, and other parts such as coil supports that facilitated the implantation of the peri-ocular device components. We begin with an overview of the implantable portion of our visual prosthesis system design, and describe in detail the micro-fabrication methods for creating the parts of our system that were assembled outside of our hermetically-sealed electronics package. We also note the unique surgical challenges that sub-retinal implantation of our micro-fabricated components presented, and how some of those issues were addressed through design, materials selection, and fabrication approaches.
- Subjects :
- high-density
Engineering
Engineering drawing
vision
retina
lcsh:Mechanical engineering and machinery
Retinal implant
education
Article
Teaching hospital
03 medical and health sciences
0302 clinical medicine
lcsh:TJ1-1570
Electronics
Electrical and Electronic Engineering
microfabrication
business.industry
Mechanical Engineering
Micro fabrication
electrode
neurostimulator
wireless
Control and Systems Engineering
Visual prosthesis
Retinal Prosthesis
New product development
030221 ophthalmology & optometry
Systems design
visual
prosthesis
business
030217 neurology & neurosurgery
neurostimulation
Subjects
Details
- Language :
- English
- ISSN :
- 2072666X
- Database :
- OpenAIRE
- Journal :
- Micromachines
- Accession number :
- edsair.doi.dedup.....5ab255b10906e3a0c2d6546ec7b7de81
- Full Text :
- https://doi.org/10.3390/mi11100944