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A non-invasive nanoparticles for multimodal imaging of ischemic myocardium in rats
- Source :
- Journal of Nanobiotechnology, Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-18 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide, and imposes a serious economic load. Thus, it is crucial to perform a timely and accurate diagnosis and monitoring in the early stage of myocardial ischemia. Currently, nanoparticles (NPs) have emerged as promising tools for multimodal imaging, because of their advantages of non-invasion, high-safety, and real-time dynamic imaging, providing valuable information for the diagnosis of heart diseases. Results In this study, we prepared a targeted nanoprobe (termed IMTP-Fe3O4-PFH NPs) with enhanced ultrasound (US), photoacoustic (PA), and magnetic resonance (MR) performance for direct and non-invasive visual imaging of ischemic myocardium in a rat model. This successfully designed nanoprobe had excellent properties such as nanoscale size, good stability, phase transformation by acoustic droplet vaporization (ADV), and favorable safety profile. Besides, it realized obvious targeting performance toward hypoxia-injured cells as well as model rat hearts. After injection of NPs through the tail vein of model rats, in vivo imaging results showed a significantly enhanced US/PA/MR signal, well indicating the remarkable feasibility of nanoprobe to distinguish the ischemic myocardium. Conclusions IMTP-Fe3O4-PFH NPs may be a promising nanoplatform for early detection of ischemic myocardium and targeted treatment under visualization for the future.
- Subjects :
- Male
lcsh:Medical technology
Dynamic imaging
lcsh:Biotechnology
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Nanoprobe
Nanoparticle
Ischemic myocardium
Bioengineering
02 engineering and technology
030204 cardiovascular system & hematology
Applied Microbiology and Biotechnology
Cell Line
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
lcsh:TP248.13-248.65
Multimodal imaging
Medicine
Animals
Non-invasive
Ultrasonography
Acoustic droplet vaporization
medicine.diagnostic_test
business.industry
Spinal Cord Ischemia
Myocardium
Research
Ultrasound
Magnetic resonance imaging
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
Rats
lcsh:R855-855.5
Molecular Medicine
Nanoparticles
0210 nano-technology
business
Preclinical imaging
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 14773155
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Nanobiotechnology
- Accession number :
- edsair.doi.dedup.....5ab05da1aa280a8d537a0f65e8d1637f