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The selective reaction of methoxyamine with cytidine residues in mammalian initiator transfer ribonucleic acid
- Source :
- Nucleic Acids Research. 1:45-52
- Publication Year :
- 1974
- Publisher :
- Oxford University Press (OUP), 1974.
-
Abstract
- Methoxyamine reacts selectively with tRNA molecules at certain exposed cytosine residues usually located in non base-paired regions of the two dimensional clover leaf structure. Here methoxyamine is used for the first time in a study of a mammalian tRNA structure. One of the sequence abnormalities of myeloma initiator tRNA is a cytosine instead of the usual uracil immediately preceding the anticodon. A study of the reaction of the cytosine residues with methoxyamine indicates that the accessibility of bases to chemical reagents in the anticodon loop of this mammalian initiator tRNA is very similar to that observed for the bacterial initiator tRNA.
- Subjects :
- Molecular Sequence Data
Codon, Initiator
Sequence (biology)
Cytidine
Biology
Hydroxylamines
Mice
chemistry.chemical_compound
RNA, Transfer
Methoxyamine
Tumor Cells, Cultured
Genetics
Animals
Molecule
RNA, Neoplasm
Binding site
Binding Sites
Base Sequence
Uracil
Articles
chemistry
Biochemistry
Transfer RNA
Nucleic Acid Conformation
Multiple Myeloma
Cytosine
Subjects
Details
- ISSN :
- 13624962 and 03051048
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Research
- Accession number :
- edsair.doi.dedup.....5aad4ee4cf0444fee144c5da6ff1cce1