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Comparison of Renal Artery, Soft Tissue, and Nerve Damage After Irrigated Versus Nonirrigated Radiofrequency Ablation
- Source :
- Circulation: Cardiovascular Interventions. 8
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Background— The long-term efficacy of radiofrequency ablation of renal autonomic nerves has been proven in nonrandomized studies. However, long-term safety of the renal artery (RA) is of concern. The aim of our study was to determine if cooling during radiofrequency ablation preserved the RA while allowing equivalent nerve damage. Methods and Results— A total of 9 swine (18 RAs) were included, and allocated to irrigated radiofrequency (n=6 RAs, temperature setting: 50°C), conventional radiofrequency (n=6 RAs, nonirrigated, temperature setting: 65°C), and high-temperature radiofrequency (n=6 RAs, nonirrigated, temperature setting: 90°C) groups. RAs were harvested at 10 days, serially sectioned from proximal to distal including perirenal tissues and examined after paraffin embedding, and staining with hematoxylin-eosin and Movat pentachrome. RAs and periarterial tissue including nerves were semiquantitatively assessed and scored. A total of 660 histological sections from 18 RAs were histologically examined by light microscopy. Arterial medial injury was significantly less in the irrigated radiofrequency group (depth of medial injury, circumferential involvement, and thinning) than that in the conventional radiofrequency group ( P P =0.003 for thinning). Severe collagen damage such as denatured collagen was also significantly less in the irrigated compared with the conventional radiofrequency group ( P P =0.36), there was a trend toward less nerve damage in the irrigated compared with conventional. Compared to conventional radiofrequency, circumferential medial damage in highest-temperature nonirrigated radiofrequency group was significantly greater ( P Conclusions— Saline irrigation significantly reduces arterial and periarterial tissue damage during radiofrequency ablation, and there is a trend toward less nerve damage.
- Subjects :
- Pathology
medicine.medical_specialty
Soft Tissue Injuries
Time Factors
Swine
Radiofrequency ablation
Kidney
law.invention
Postoperative Complications
Renal Artery
law
medicine.artery
Tissue damage
medicine
Animals
Humans
Autonomic Pathways
Paraffin embedding
Renal artery
Therapeutic Irrigation
business.industry
Saline irrigation
Temperature
Soft tissue
Radiofrequency catheter ablation
Models, Animal
Catheter Ablation
Collagen
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
Subjects
Details
- ISSN :
- 19417632 and 19417640
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Circulation: Cardiovascular Interventions
- Accession number :
- edsair.doi.dedup.....5a9bf5c139cb309b7a3e6622a81bd131