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Characterization of Global Patterns and the Genetics of Fusidic Acid Resistance
- Source :
- Clinical Infectious Diseases. 52:S487-S492
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Fusidic acid binds to elongation factor G (EF-G), preventing its release from the ribosome, thus stalling bacterial protein synthesis. In staphylococci, high-level fusidic acid resistance is usually caused by mutations in the gene encoding EF-G, fusA, and low-level resistance is generally caused by the horizontally transferable mechanisms fusB and fusC that have a putative protective role on EF-G. In addition, fusD is responsible for intrinsic resistance in Staphylococcus saprophyticus, and alterations in the L6 portion of rplF (fusE) have a role in fusidic acid resistance. Fusidic acid has been used in Europe and Australia for decades. More recently, it has also been used in other countries and regions, but not in the United States. Worldwide fusidic acid resistance has been slow to develop, and the level of resistance and genetic mechanisms responsible generally reflect the time since introduction, indications for treatment, route of administration, and prescribing practices.
- Subjects :
- Microbiology (medical)
Staphylococcus
Fusidic acid
Microbial Sensitivity Tests
Drug resistance
Biology
Global Health
medicine.disease_cause
Microbiology
Bacterial genetics
Bacterial Proteins
Drug Resistance, Bacterial
medicine
Humans
Peptide Elongation Factor G
Gene
Genetics
Mutation
Staphylococcus saprophyticus
biology.organism_classification
Anti-Bacterial Agents
Infectious Diseases
Fusidic Acid
medicine.drug
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....5a9bc260d5c7762f795be2825f3fb486