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Peroxisomal protein import pores
- Source :
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863:821-827
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Peroxisomal protein import is essentially different to the translocation of proteins into other organelles. The molecular mechanisms by which completely folded or even oligomerized proteins cross the peroxisomal membrane remain to be disclosed. The identification of a water-filled pore that is mainly constituted by Pex5 and Pex14 led to the assumption that proteins are translocated through a large, probably transient, protein-conducting channel. Here, we will review the work that led to the identification of this translocation pore. In addition, we will discuss the main biophysical features of the pore and compare it with other protein–translocation channels.
- Subjects :
- 0301 basic medicine
Peroxisome-Targeting Signal 1 Receptor
Saccharomyces cerevisiae
Receptors, Cytoplasmic and Nuclear
Chromosomal translocation
Protein Sorting Signals
Biology
Protein Structure, Secondary
03 medical and health sciences
Organelle
Peroxisomes
Animals
Humans
Protein Isoforms
Molecular Biology
Peroxisomal Targeting Signal 2 Receptor
Plant Proteins
Regulation of gene expression
Cell Biology
Plants
Peroxisome
biology.organism_classification
Protein Structure, Tertiary
Cell biology
Transport protein
Protein Transport
Eukaryotic Cells
030104 developmental biology
Gene Expression Regulation
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 01674889
- Volume :
- 1863
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Accession number :
- edsair.doi.dedup.....5a98ae6422dbfa10335b8df8262f6628