Back to Search
Start Over
Aspirin moderates the association between cardiovascular risk, brain white matter hyperintensity total lesion volume and processing speed in normal ageing
- Source :
- Maturitas. 133:49-53
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Cardiovascular risk is associated with cognitive decline and this effect is attributed to brain pathology, including white matter hyperintensity (WMH) burden. Low-dose aspirin is frequently recommended for reducing vascular events. We investigated the effect of taking aspirin on the association between cardiovascular risk, WMH burden and cognitive function.The study sample was drawn from 318 dementia-free adults aged 67-71 years. Brain magnetic resonance imaging (MRI) scans were acquired from 239 participants.WMH total lesion volumes (TLV) were extracted using the automated lesion segmentation algorithm. We measured cardiovascular risk by calculating ASSIGN score. Cognitive ability was measured using a test of processing speed. We developed structural equation models to test our hypothesis.Sixty-eight participants (47.1 % male, mean age = 68.8 years) reported that they took aspirin. The demographic measures did not differ significantly by aspirin use. Among aspirin users, there was a strong negative association between WMH TLV and cognition (β = -0.43, p-value0.001), while in non-users of aspirin the only significant predictor of poorer cognition was cardiovascular risk (β = -0.17, p-value = 0.001).Aspirin use moderates the negative effect of WMH burden on cognition. Considering WMH burden in addition to cardiovascular risk could improve the prediction of cognitive decline in older adults with aspirin use.
- Subjects :
- Male
Aging
medicine.medical_specialty
General Biochemistry, Genetics and Molecular Biology
Lesion
03 medical and health sciences
Cognition
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Dementia
030212 general & internal medicine
Cognitive decline
Association (psychology)
Aged
Aspirin
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
medicine.disease
Magnetic Resonance Imaging
White Matter
Hyperintensity
Cardiovascular Diseases
Ageing
Cardiology
Female
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 03785122
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Maturitas
- Accession number :
- edsair.doi.dedup.....5a5dec80b7ec21cc81bb4709a5c36533