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The impact of glycemic variability on diabetic peripheral neuropathy
- Source :
- Endocrine. 53:643-648
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Mean glucose values alone cannot explain the patterns of morbidity and mortality due to dysglycemia in diabetes. Development of continuous glucose monitoring systems has improved the analysis and interpretation of glycemic variability. The roles of glycemic components other than constant hyperglycemia in diabetic complications must be investigated because large clinical studies have indicated that risk factors besides the average glucose value of HbA1c are involved in chronic macrocomplications/microcomplications of diabetes. Among these complications, the pathogenesis of diabetic peripheral neuropathy is particularly complex, and several factors related to glucose and nonglucose pathways have been suggested as risk factors. There is little information regarding the effect of glycemic variability on diabetic peripheral neuropathy, unlike other microvascular complications of retinopathy and nephropathy, and whether glycemic variability causes harmful effects is still a matter of debate. In this review, we discuss the relationships between glycemic variability and diabetic peripheral neuropathy, focusing on somatosensory peripheral neuropathies rather than autonomic neuropathies.
- Subjects :
- Blood Glucose
medicine.medical_specialty
business.industry
Continuous glucose monitoring
Endocrinology, Diabetes and Metabolism
Peripheral Nervous System Diseases
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
medicine.disease
Peripheral
Nephropathy
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Endocrinology
Peripheral neuropathy
Diabetic Neuropathies
Internal medicine
Diabetes mellitus
Humans
Medicine
business
Retinopathy
Glycemic
Subjects
Details
- ISSN :
- 15590100 and 1355008X
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Endocrine
- Accession number :
- edsair.doi.dedup.....5a5c1d754bfb34a4542adb80404b0e28