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Impact of maternal immunization on influenza hospitalizations in infants

Authors :
Mary Allen Staat
Beverly M. Snively
Peter G. Szilagyi
Lyn Finelli
Susan Y. Chu
Carolyn B. Bridges
Laney S. Light
Katherine A. Poehling
Daniel C. Payne
Mila M. Prill
Kathryn M. Edwards
Marie R. Griffin
Source :
American Journal of Obstetrics and Gynecology. 204:S141-S148
Publication Year :
2011
Publisher :
Elsevier BV, 2011.

Abstract

We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.

Details

ISSN :
00029378
Volume :
204
Database :
OpenAIRE
Journal :
American Journal of Obstetrics and Gynecology
Accession number :
edsair.doi.dedup.....5a4ed2c5cc238e6901132b65c7ee83b1
Full Text :
https://doi.org/10.1016/j.ajog.2011.02.042