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Impact of maternal immunization on influenza hospitalizations in infants
- Source :
- American Journal of Obstetrics and Gynecology. 204:S141-S148
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.
- Subjects :
- Risk
Reduced risk
Pediatrics
medicine.medical_specialty
Influenza vaccine
Maternal vaccination
Article
Pregnancy
Influenza, Human
Humans
Medicine
Pregnancy Complications, Infectious
business.industry
Infant
Obstetrics and Gynecology
medicine.disease
United States
Hospitalization
Vaccination
Immunization
Influenza Vaccines
Population Surveillance
Practice Guidelines as Topic
Immunology
Female
Viral disease
business
Immunity, Maternally-Acquired
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 204
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....5a4ed2c5cc238e6901132b65c7ee83b1
- Full Text :
- https://doi.org/10.1016/j.ajog.2011.02.042