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Modifications on antioxidant capacity and lipid peroxidation in mice under fraxetin treatment
- Source :
- Scopus-Elsevier
-
Abstract
- Fraxetin belongs to an extensive group of natural phenolic antioxidants. We have investigated the modifications in endogenous antioxidant capacity; superoxide dismutase (SOD), catalase (CAT), total and selenium-dependent glutathione peroxidases (GPx) and glutathione reductase (GR) and stress index; glutathione disulphide (GSSG)/reduced glutathione (GSH) ratio and thiobarbituric acid-reactive substances (TBARs) in liver and brain supernatants of C57BL/6J male 12-month-old mice under fraxetin treatment for 30 days. Liver SOD and GPx (total and Se-dependent) activities were not significantly affected by fraxetin, whereas they were increased in the brain compared with control animals. GR activity increased significantly only in the liver of treated mice. Fraxetin treatment-related decreases were shown for GSSG/GSH ratio and rate of accumulation of TBARs (not significant in TBARs) in both tissues. We concluded that the net effect of fraxetin treatment on endogenous antioxidant capacity suggests that this compound might provide an important resistance to, or protection against, free-radical-mediated events which contribute to degenerative diseases of ageing.
- Subjects :
- Male
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Glutathione reductase
Pharmaceutical Science
Antioxidants
Superoxide dismutase
Lipid peroxidation
Mice
chemistry.chemical_compound
Coumarins
Internal medicine
medicine
TBARS
Animals
Pharmacology
chemistry.chemical_classification
Glutathione Peroxidase
biology
Superoxide Dismutase
Chemistry
Glutathione peroxidase
Glutathione
Catalase
Mice, Inbred C57BL
Endocrinology
Biochemistry
biology.protein
Fraxetin
Lipid Peroxidation
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....5a4abb0ccb49900b770bd2dd51cf33ad