Back to Search
Start Over
Ca 2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity
- Source :
- Biophysical Journal. 110:733-742
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Pancreatic islets respond to elevated blood glucose by secreting pulses of insulin that parallel oscillations in β-cell metabolism, intracellular Ca(2+) concentration, and bursting electrical activity. The mechanisms that maintain an oscillatory response are not fully understood, yet several models have been proposed. Only some can account for experiments supporting that metabolism is intrinsically oscillatory in β-cells. The dual oscillator model (DOM) implicates glycolysis as the source of oscillatory metabolism. In the companion article, we use recently developed biosensors to confirm that glycolysis is oscillatory and further elucidate the coordination of metabolic and electrical signals in the insulin secretory pathway. In this report, we modify the DOM by incorporating an established link between metabolism and intracellular Ca(2+) to reconcile model predictions with experimental observations from the companion article. With modification, we maintain the distinguishing feature of the DOM, oscillatory glycolysis, but introduce the ability of Ca(2+) influx to reshape glycolytic oscillations by promoting glycolytic efflux. We use the modified model to explain measurements from the companion article and from previously published experiments with islets.
- Subjects :
- 0301 basic medicine
Periodicity
medicine.medical_treatment
Biophysics
Action Potentials
030209 endocrinology & metabolism
Biology
03 medical and health sciences
Bursting
chemistry.chemical_compound
Adenosine Triphosphate
0302 clinical medicine
Insulin-Secreting Cells
medicine
Animals
Humans
Glycolysis
Calcium Signaling
Secretory pathway
Calcium signaling
Systems Biophysics
Insulin
Pancreatic islets
Metabolism
Models, Theoretical
030104 developmental biology
medicine.anatomical_structure
Biochemistry
chemistry
Calcium
Energy Metabolism
Adenosine triphosphate
Subjects
Details
- ISSN :
- 00063495
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Biophysical Journal
- Accession number :
- edsair.doi.dedup.....5a4407117ef90137254e42d426ee1646