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Optimal maturation of the SIV-specific CD8 + T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Highly efficient virus-specific CD8+ T-cells are associated with immune control of HIV infection, but it remains unclear how these cells are generated and maintained over time. We used a macaque model of spontaneous control of SIVmac251 infection to monitor the development and evolution of potent antiviral CD8+ T-cell responses. SIV-specific CD8+ T-cells emerged during primary infection in all animals. However, the ability of CD8+ T cells to suppress SIV replication was low in early stages but increased after a period of maturation, temporally linked with the establishment of sustained low-level viremia in controller macaques. SIV-specific CD8+ T-cells with a central memory phenotype expressed higher levels of survival markers in controllers versus non-controllers. In contrast, a persistently skewed differentiation phenotype was observed among central memory SIV-specific CD8+ T-cells in non-controllers since primary infection, typified by relatively high expression levels of T-bet.Collectively, these data show that the phenotype of SIV-specific CD8+ T-cells defined early after SIV infection favor the gain of antiviral potency as a function of time in controllers, whereas SIV-specific CD8+ T-cell responses in non-controllers fail to gain antiviral potency due to early defects imprinted in the central memory pool.
- Subjects :
- 0303 health sciences
[SDV.IMM] Life Sciences [q-bio]/Immunology
Period (gene)
animal diseases
Memory pool
virus diseases
Viremia
Biology
medicine.disease
Phenotype
Macaque
3. Good health
03 medical and health sciences
0302 clinical medicine
biology.animal
Immunology
medicine
Potency
Cytotoxic T cell
[SDV.IMM]Life Sciences [q-bio]/Immunology
CD8
030304 developmental biology
030215 immunology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5a2353df5baa7b07a50113f5a76c3e7a