Increase in sex-dependent expression of prolactin receptors after intrahepatic transplantation of H27 rat hepatoma cells

Immunohistochemical study revealed overexpression of prolactin receptors in central and peripheral cells of intrahepatic grafts from H27 rat hepatoma without changes in compartmentalization compared to hepatocytes of intact animals. Experiments with gonadectomized animals showed that the hormonal regulation of prolactin receptors in both types of tumor cells does not differ from that in normal liver cells (positive estrogen-dependent regulation and negative androgen-dependent regulation).