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Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors
- Source :
- Diagnostic Pathology, Vol 7, Iss 1, p 1 (2012), Diagnostic Pathology
- Publication Year :
- 2012
- Publisher :
- BMC, 2012.
-
Abstract
- The diagnosis of uterine smooth muscle tumors depends on a combination of microscopic features. However, a small number of these tumors still pose difficult diagnostic challenges. To investigate progesterone receptor (PR) and p53 expression in leiomyomas (LMs), atypical leiomyomas (ALMs), smooth muscle tumors of uncertain malignant potential (STUMP), and leiomyosarcomas (LMSs) and to evaluate the potential utility of the selected immunohistochemical markers in differentiating these tumors. Immunohistochemical expression of PR and p53 was investigated in 41 uterine smooth muscle tumors comprising: 15 LMS, 4 STUMP, 6 ALM and 16 LM. Quantitative evaluation of PR and p53 expression was graded on a scale from 0 to 3+. Leiomyosarcomas showed reduced PR expression. All LMs as well as ALMs and STUMP were stained intensely for PR. Conversely, LMS was strongly stained with p53, while the three non-sarcomatous groups (STUMP, ALM, LM) were either entirely negative or weakly stained for p53. Regarding both PR and p53 expression, the difference between the LMS group and the three non-sarcomatous groups was highly significant (p < 0.001). Combined high PR - low p53 expression was seen in all the 26 examined cases of the non-sarcomatous group including the STUMP cases and none of the LMS cases. Therefore, it represents a "benign" profile with 100% specificity in diagnosis of a non-sarcomatous tumor. Immunohistochemistry for PR and p53 is valuable as an adjunct tool to morphological assessment of problematic uterine smooth muscle tumors. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1033065653646058 .
- Subjects :
- Leiomyosarcoma
p53
Pathology
medicine.medical_specialty
Histology
Biology
PR
Pathology and Forensic Medicine
Diagnosis, Differential
Predictive Value of Tests
Progesterone receptor
medicine
Biomarkers, Tumor
lcsh:Pathology
Humans
Receptor
Uterine Neoplasm
uterine smooth muscle tumor
Retrospective Studies
Chi-Square Distribution
Leiomyoma
Research
STUMP
General Medicine
medicine.disease
Prognosis
Immunohistochemistry
body regions
Smooth Muscle Tumor
Uterine Neoplasms
Egypt
Female
Differential diagnosis
Tumor Suppressor Protein p53
Receptors, Progesterone
lcsh:RB1-214
Subjects
Details
- Language :
- English
- ISSN :
- 17461596
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diagnostic Pathology
- Accession number :
- edsair.doi.dedup.....5a1721638b0f1b72af9dac824e73722e