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Hemorrhage of hepatocellular adenoma: a complication that can be treated by conservative management without surgery
- Source :
- HPB. 20:1198-1205
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Hemorrhage is the main complication of hepatocellular adenoma (HCA). The aim of this study was to describe a single center's evolving management of patients with hemorrhagic HCA.Between 1990 and 2013, all patients with hemorrhagic HCA were included. During the study period, the management evolved from urgent surgery (period2004) to arterial embolization with (period, 2004-2010) or without (period 2010) delayed resection.A total of 56 patients were identified. The median (range) size of HCA and the hematoma was 80 mm (35-160) and 50 mm (10-160). Patients were treated by urgent resection (group 1, n = 6), delayed resection with or without embolization (group 2, n = 43) and systematic embolization without surgery (group 3, n = 7). Embolization was performed in 0/6, 15/43 and 7/7 in groups 1, 2 and 3. Urgent resection was associated with higher morbidity (p 0.001). Complete necrosis was observed in 0/6, 13/43 and 3/7 patients, and on histology it was associated with embolization (p = 0.001), a hematoma-tumor ratio 60% (p = 0.046) and a cystic non-viable lesion before surgery (p 0.001).Hemodynamic stability can be achieved in patients presenting with hemorrhagic HCA by none surgical means. Subsequent surgery can be completely avoided with such an approach in up to 40% of patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Databases, Factual
Conservative management
medicine.medical_treatment
Hemorrhage
030230 surgery
Conservative Treatment
Single Center
Adenoma, Liver Cell
Resection
Lesion
Young Adult
03 medical and health sciences
0302 clinical medicine
Hematoma
medicine
Humans
Embolization
Retrospective Studies
Hepatology
business.industry
Liver Neoplasms
Hemodynamics
Gastroenterology
Middle Aged
Hepatocellular adenoma
medicine.disease
Embolization, Therapeutic
Hemostasis, Surgical
Surgery
Treatment Outcome
Female
030211 gastroenterology & hepatology
medicine.symptom
Complication
business
Subjects
Details
- ISSN :
- 1365182X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- HPB
- Accession number :
- edsair.doi.dedup.....5a15f022e09a34ef090f5601cf7e0d73