Back to Search
Start Over
Comparison of Sufentanil- and Fentanyl-based Intravenous Patient-controlled Analgesia on Postoperative Nausea and Vomiting after Laparoscopic Nephrectomy: A Prospective, Double-blind, Randomized-controlled Trial
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2020
- Publisher :
- Ivyspring International Publisher, 2020.
-
Abstract
- Background: The incidence of postoperative nausea and vomiting (PONV) remains high. The effects of sufentanil for PONV is not firmly confirmed. The aim of this study was to compare the effect of sufentanil- and fentanyl-based intravenous patient-controlled analgesia (IV-PCA) on the incidence of PONV after laparoscopic nephrectomy. Methods: Eighty-six patients were randomly allocated to receive either the sufentanil (n =43) or fentanyl (n =43). IV-PCA was prepared using either sufentanil 3 µg/kg or fentanyl 20 µg/kg, ramosetron 0.3 mg, and ketorolac 120 mg. The primary outcome of was the incidence of PONV during 24 h after post anesthesia care unit (PACU) discharge. The secondary outcomes were the modified Rhodes index and patient satisfaction scores at 24 h after PACU discharge, need for rescue antiemetics, pain score, need for additional analgesics, and cumulative consumption of IV-PCA Results: The incidence of PONV was comparable between the sufentanil and fentanyl groups (64.3% vs. 65%, p = 0.946; respectively). The number of patients who required antiemetics (p = 0.946) and the modified Rhodes index at 24 h after post-anesthesia care unit discharge (p = 0.668) were also comparable in both groups. No significant differences were found in the secondary outcomes, including the analgesic profiles and adverse events between the groups. Conclusions: In conclusion, sufentanil- and fentanyl-based IV-PCA showed similar incidence of PONV with comparable analgesic effects after laparoscopic nephrectomy. Based on these results, we suggest that sufentanil and fentanyl may provide comparable effects for IV-PCA after laparoscopic nephrectomy.
- Subjects :
- Adult
Sufentanil
postoperative nausea and vomiting
fentanyl
Nephrectomy
Fentanyl
Ramosetron
Pacu
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Double-Blind Method
medicine
Post-anesthesia care unit
Humans
Prospective Studies
laparoscopic nephrectomy
Aged
biology
business.industry
Analgesia, Patient-Controlled
General Medicine
Middle Aged
intravenous patient-controlled analgesia
biology.organism_classification
Ketorolac
chemistry
Anesthesia
Laparoscopy
030211 gastroenterology & hepatology
medicine.symptom
business
Postoperative nausea and vomiting
Research Paper
medicine.drug
Intravenous Patient-Controlled Analgesia
Subjects
Details
- ISSN :
- 14491907
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- International Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....59fac2ef5ebbbe0ce0e57dcd1b5b2586