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Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/β-catenin
- Source :
- Cell Death & Disease
- Publication Year :
- 2017
-
Abstract
- Tobacco smoke (TS) is the most important single risk factor for bladder cancer. Epithelial–mesenchymal transition (EMT) is a transdifferentiation process, involved in the initiation of TS-related cancer. Cancer stem cells (CSCs) have an essential role in the progression of many tumors including TS-related cancer. However, the molecular mechanisms of TS exposure induced urocystic EMT and acquisition of CSCs properties remains undefined. Wnt/β-catenin pathway is critical for EMT and the maintenance of CSCs. The aim of our present study was to investigate the role of Wnt/β-catenin pathway in chronic TS exposure induced urocystic EMT, stemness acquisition and the preventive effect of curcumin. Long time TS exposure induced EMT changes and the levels of CSCs’ markers were significant upregulated. Furthermore, we demonstrated that Wnt/β-catenin pathway modulated TS-triggered EMT and stemness, as evidenced by the findings that TS elevated Wnt/β-catenin activation, and that TS-mediated EMT and stemness were attenuated by Wnt/β-catenin inhibition. Treatment of curcumin reversed TS-elicited activation of Wnt/β-catenin, EMT and CSCs properties. Collectively, these data indicated the regulatory role of Wnt/β-catenin in TS-triggered urocystic EMT, acquisition of CSCs properties and the chemopreventive effect of curcumin.
- Subjects :
- 0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
Curcumin
Epithelial-Mesenchymal Transition
Immunology
Biology
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
Cancer stem cell
Risk Factors
Cell Line, Tumor
medicine
Tobacco Smoking
Humans
Epithelial–mesenchymal transition
Wnt Signaling Pathway
Transdifferentiation
Wnt signaling pathway
Cancer
Cell Biology
medicine.disease
030104 developmental biology
Cell Transformation, Neoplastic
chemistry
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Catenin
embryonic structures
Cell Transdifferentiation
Cancer research
Neoplastic Stem Cells
Original Article
Subjects
Details
- ISSN :
- 20414889
- Volume :
- 8
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cell deathdisease
- Accession number :
- edsair.doi.dedup.....59e17626d4351e42ac3b16c828a96fc2