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Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors
- Source :
- Applied Optics; 41(7), pp 1462-1468 (2002), Scopus-Elsevier
- Publication Year :
- 2002
- Publisher :
- Optical Society of America, 2002.
-
Abstract
- A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development. The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared.
- Subjects :
- Optical fiber
Materials science
Light
Materials Science (miscellaneous)
medicine.medical_treatment
Rats, Inbred WF
Photodynamic therapy
Radiation
Adenocarcinoma
Industrial and Manufacturing Engineering
Fluorescence
law.invention
Clinical work
Optics
Light propagation
law
medicine
Dosimetry
Light Dosimetry
Animals
Business and International Management
Radiometry
business.industry
Laser
Hindlimb
Rats
Photochemotherapy
Cancer and Oncology
Feasibility Studies
Laser Therapy
business
Neoplasm Transplantation
Software
Subjects
Details
- Language :
- English
- ISSN :
- 21553165
- Database :
- OpenAIRE
- Journal :
- Applied Optics; 41(7), pp 1462-1468 (2002), Scopus-Elsevier
- Accession number :
- edsair.doi.dedup.....59d03149d517f6f0e2a960f5ef27b2a5