Back to Search
Start Over
Tobacco smoking and intestinal metaplasia: Systematic review and meta-analysis
Tobacco smoking and intestinal metaplasia: Systematic review and meta-analysis
- Source :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 46(11)
- Publication Year :
- 2014
-
Abstract
- Background The evaluation of specific risk factors for early endpoints in the gastric carcinogenesis pathway may further contribute to the understanding of gastric cancer aetiology. Aims To quantify the relation between smoking and intestinal metaplasia through systematic review and meta-analysis. Methods Articles providing data on the association between smoking and intestinal metaplasia were identified in PubMed ® , Scopus ® and Web of Science™, searched until April 2014, and through backward citation tracking. Summary odds ratio estimates and 95% confidence intervals were computed using the DerSimonian and Laird method. Heterogeneity was quantitatively assessed using the I 2 statistic. Results A total of 32 articles were included in this systematic review and 19 provided data for meta-analysis. Smoking was defined as ever vs. never (crude estimates, six studies, summary odds ratio = 1.54, 95% confidence interval: 1.12–2.12, I 2 = 67.4%; adjusted estimates, seven studies, summary odds ratio = 1.26, 95% confidence interval: 0.98–1.61, I 2 = 65.0%) and current vs. non-smokers (crude estimates, seven studies, summary odds ratio = 1.27, 95% confidence interval: 0.88–1.84, I 2 = 73.4%; adjusted estimates, two studies, summary odds ratio 1.49, 95% confidence interval: 0.99–2.25, I 2 = 0.0%). Conclusion The weak and non-statistically significant association found through meta-analysis of the available evidence does not confirm smoking as an independent risk factor for intestinal metaplasia.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Risk Assessment
Odds
03 medical and health sciences
0302 clinical medicine
Age Distribution
Stomach Neoplasms
Internal medicine
Intestinal Neoplasms
Confidence Intervals
Odds Ratio
Prevalence
Medicine
Humans
Risk factor
Sex Distribution
Survival rate
Aged
Metaplasia
Hepatology
Portugal
business.industry
Smoking
Gastroenterology
Intestinal metaplasia
Odds ratio
Middle Aged
medicine.disease
Prognosis
Confidence interval
3. Good health
Survival Rate
030220 oncology & carcinogenesis
Meta-analysis
030211 gastroenterology & hepatology
Female
Risk assessment
business
Precancerous Conditions
Subjects
Details
- ISSN :
- 18783562
- Volume :
- 46
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Accession number :
- edsair.doi.dedup.....59c81e492ba965bbe856f59e2b985244