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Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2002
- Publisher :
- Rockefeller University Press, 2002.
-
Abstract
- The cytokine potential of developing T helper (Th) cells is directly shaped both positively and negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the recently identified cytokine, interleukin (IL)-21, is preferentially expressed by Th2 cells when compared with Th1 cells generated in vitro and in vivo. Exposure of naive Th precursors to IL-21 inhibits interferon (IFN)-γ production from developing Th1 cells. The repression of IFN-γ production is specific in that the expression of other Th1 and Th2 cytokines is unaffected. IL-21 decreases the IL-12 responsiveness of developing Th cells by specifically reducing both signal transducer and activator of transcription 4 protein and mRNA expression. These results suggest that Th2 cell-derived IL-21 regulates the development of IFN-γ–producing Th1 cells which could serve to amplify a Th2 response.
- Subjects :
- Immunology
Article
Interferon-gamma
Mice
03 medical and health sciences
Interleukin 21
0302 clinical medicine
Animals
Immunology and Allergy
IL-2 receptor
Interleukin 4
030304 developmental biology
Interleukin 3
0303 health sciences
immunosuppression
CD40
biology
Interleukins
Cell Differentiation
T-Lymphocytes, Helper-Inducer
Th1 Cells
cytokines
Cell biology
Mice, Inbred C57BL
Interleukin 33
Interleukin 15
T lymphocytes helper inducer
Interleukin 12
biology.protein
030215 immunology
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 196
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....59b443e03575220fb74c141b4d717b91
- Full Text :
- https://doi.org/10.1084/jem.20020620