Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration

Authors :: Victoria Liu
Angela N. Lewis
Lila S. Nolan
Elizabeth Huang
Qingqing Gong
Misty Good
P. K. Agrawal
Martin Goree
Pawan Kumar
Olivia B. Parks
Jamie M. Rimer
Cliff J. Luke
Wyatt E. Lanik
Belgacem Mihi
Elise Hu
Sarah E. Gale
Shay S. Bidani
Jay K. Kolls
Marie L. Laury
Source :: Cell Reports Medicine, Vol 2, Iss 6, Pp 100320-(2021), Cell Reports Medicine
Publication Year :: 2021
Publisher :: Elsevier, 2021.
Abstract: Necrotizing enterocolitis (NEC) is an intestinal disorder that disproportionately affects premature infants and lacks in effective therapeutics. Mihi and colleagues1 demonstrated that the cytokine interleukin-22 promotes intestinal epithelial regeneration and reduces disease severity in an experimental model of NEC.<br />Necrotizing enterocolitis (NEC) is an intestinal disorder that disproportionately affects premature infants and lacks in effective therapeutics. Mihi and colleagues demonstrated that the cytokine interleukin-22 promotes intestinal epithelial regeneration and reduces disease severity in an experimental model of NEC.

Subjects :: Medicine (General)
Chemokine CXCL1
Chemokine CXCL2
Interleukin-1beta
microbiome
Inflammation
Weaning
intestinal immunity
General Biochemistry, Genetics and Molecular Biology
Infant, Newborn, Diseases
Interleukin 22
Mice
R5-920
Enterocolitis, Necrotizing
Medicine
Animals
Humans
Protein Isoforms
Intestinal Mucosa
Receptor
Mice, Knockout
necrotizing enterocolitis
business.industry
Regeneration (biology)
Interleukins
interleukin-22
Infant, Newborn
Interleukin
Gene Expression Regulation, Developmental
Receptors, Interleukin
medicine.disease
Preview
Epithelium
Recombinant Proteins
digestive system diseases
epithelial cells
Gastrointestinal Microbiome
Disease Models, Animal
medicine.anatomical_structure
Animals, Newborn
regeneration
Necrotizing enterocolitis
Immunology
medicine.symptom
business
Homeostasis
Infant, Premature
Signal Transduction

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