Back to Search
Start Over
Novel Human Adenovirus Causing Nosocomial Epidemic Keratoconjunctivitis
- Source :
- Journal of Clinical Microbiology. 46:2002-2008
- Publication Year :
- 2008
- Publisher :
- American Society for Microbiology, 2008.
-
Abstract
- In 2000, we encountered cases of nosocomial infections with epidemic keratoconjunctivitis (EKC) at a university hospital in Kobe, in the western part of Japan. Two human adenovirus (HAdV) strains, Kobe-H and Kobe-S, were isolated from patients with nosocomial EKC infection. They were untypeable by existing neutralizing antisera; however, the isolate was neutralized with homologous antisera. We then encountered several cases of EKC due to nosocomial infections in eye clinics in different parts of Japan. A total of 80 HAdVs were isolated from patients with EKC at eight different hospitals. The partial hexon gene sequences of the isolates were determined and compared to those of the prototype strains of 51 serotypes. All isolates had identical partial hexon nucleotide sequences. Phylogenetic analysis classified these isolates into species of HAdV-D. The isolates showed 93.9 to 96.7% nucleotide identity with HAdV-D prototype strains, while all 32 HAdV-D prototype strains ranged from 93.2 to 99.2% identity. The sequences of the loop 2 and fiber knob regions from the representative strain, Kobe-H, were dissimilar in all prototype strains of 51 serotypes. We believe that this virus is a novel serotype of HAdV that causes EKC.
- Subjects :
- Microbiology (medical)
Serotype
Molecular Sequence Data
Keratoconjunctivitis
Virus
Disease Outbreaks
Microbiology
Adenovirus Infections, Human
Conjunctivitis, Viral
Japan
Phylogenetics
Virology
medicine
Humans
Phylogeny
Cross Infection
biology
Phylogenetic tree
Adenoviruses, Human
virus diseases
Sequence Analysis, DNA
medicine.disease
biology.organism_classification
eye diseases
Epidemic Keratoconjunctivitis
Mastadenovirus
Capsid Proteins
Viral disease
Subjects
Details
- ISSN :
- 1098660X and 00951137
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Microbiology
- Accession number :
- edsair.doi.dedup.....5992f70eff6393bb2da620e9955117dc