Back to Search
Start Over
Dipeptidyl-peptidase-like protein 6 encephalitis treated with immunotherapy
- Source :
- Proc (Bayl Univ Med Cent)
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- This case describes a middle-aged man with anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis who exhibited the triad of memory loss, diarrhea, and tremor. The progression of his disease resembled neurodegenerative disease, and his first presentation at our department was 2 years after the first onset of symptoms. Antibodies against DPPX were positive in both serum and cerebrospinal fluid. No related tumor was found. The patient was initially treated with corticosteroid therapy and plasmapheresis. Despite moderate response to this treatment, corticosteroids were ceased because of adverse effects such as Cushing syndrome, deep vein thrombosis, and osteoporosis. After five cycles of treatment with rituximab, the patient experienced no further progression of neurologic symptoms and no adverse effects. The case adds to the understanding of the diagnosis, treatment, and potential prognosis of anti-DPPX encephalitis.
- Subjects :
- Autoimmune encephalitis
medicine.medical_specialty
business.industry
medicine.medical_treatment
Deep vein
General Medicine
medicine.disease
Thrombosis
Gastroenterology
Cushing syndrome
Case Studies
medicine.anatomical_structure
Internal medicine
Medicine
Plasmapheresis
Rituximab
business
Adverse effect
Encephalitis
medicine.drug
Subjects
Details
- ISSN :
- 15253252 and 08998280
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Baylor University Medical Center Proceedings
- Accession number :
- edsair.doi.dedup.....59929f879d223cce95d18a98db3b2926