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Prognostic Value of MicroRNA-15a in Human Cancers: A Meta-Analysis and Bioinformatics
- Source :
- BioMed Research International, BioMed Research International, Vol 2019 (2019)
- Publication Year :
- 2019
- Publisher :
- Hindawi Limited, 2019.
-
Abstract
- Background.Although several studies have proved the relationship between the prognostic value of miRNA-15a and different types of cancer, the result remains controversial. Thus, a meta-analysis was conducted to clarify the prognostic value of miRNA-15a expression level in human cancers.Methods.We enrolled appropriate literature by searching the databases of PubMed, Embase, and Web of Science. Subsequently, we extracted HRs and their 95% CIs and calculated pooled results of miRNA-15a for overall survival (OS) and disease-free survival (DFS). Besides, subgroup analysis, sensitivity analysis, and publication bias were also revealed in this study. We also further validated this meta-analysis using the Kaplan-Meier plotter database.Result.10 studies, including 1616 patients, were embraced in our meta-analysis. The result showed the lower expression of miRNA-15a significantly predicted adverse OS (HR=2.17, 95% CI: 1.41-3.34), but there is no significant association between the expressing level and DFS in cancer patient (HR=2.04, 95% CI: 0.60-6.88). Based on Kaplan-Meier plotter database, we found the same results in bladder Carcinoma, head-neck squamous cell carcinoma, liver hepatocellular carcinoma, lung squamous cell carcinoma, pancreatic ductal adenocarcinoma, rectum adenocarcinoma, stomach adenocarcinoma, and uterine corpus endometrial carcinoma, but opposite results were found in cervical squamous cell carcinoma and esophageal carcinoma.Conclusion.Low expressing levels of miRNA-15a indicated poor OS, while miRNA-15a can be used as a prediction biomarker in different cancer types.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
lcsh:Medicine
Rectum
Review Article
Disease-Free Survival
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Neoplasms
Internal medicine
Biomarkers, Tumor
medicine
Carcinoma
Humans
RNA, Neoplasm
Survival rate
General Immunology and Microbiology
business.industry
lcsh:R
Computational Biology
Cancer
General Medicine
medicine.disease
Gene Expression Regulation, Neoplastic
Survival Rate
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Meta-analysis
Adenocarcinoma
Biomarker (medicine)
business
Subjects
Details
- ISSN :
- 23146141 and 23146133
- Volume :
- 2019
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....5982f4c60c4254db179ec45ff6148690
- Full Text :
- https://doi.org/10.1155/2019/2063823