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Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern
- Source :
- Cardiovasc Res
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Aims Conflicting data exist supporting differing mechanisms for sustaining ventricular fibrillation (VF), ranging from disorganised multiple-wavelet activation to organised rotational activities (RAs). Abnormal gap junction (GJ) coupling and fibrosis are important in initiation and maintenance of VF. We investigated whether differing ventricular fibrosis patterns and the degree of GJ coupling affected the underlying VF mechanism. Methods and Results Optical mapping of 65 Langendorff-perfused rat hearts was performed to study VF mechanisms in control hearts with acute GJ modulation, and separately in three differing chronic ventricular fibrosis models; compact (CF), diffuse (DiF) and patchy (PF). VF dynamics were quantified with phase mapping and frequency dominance index (FDI) analysis, a power ratio of the highest amplitude dominant frequency in the cardiac frequency spectrum. Enhanced GJ coupling with rotigaptide (n = 10) progressively organised fibrillation in a concentration-dependent manner; increasing FDI (0nM: 0.53±0.04, 80nM: 0.78±0.03, p
- Subjects :
- medicine.medical_specialty
Time Factors
Physiology
Heart Ventricles
Carbenoxolone
Action Potentials
Rats, Sprague-Dawley
Electrocardiography
chemistry.chemical_compound
Heart Rate
Fibrosis
Physiology (medical)
Internal medicine
Optical mapping
medicine
Animals
Rotigaptide
1102 Cardiorespiratory Medicine and Haematology
Fibrillation
business.industry
Models, Cardiovascular
Editorials
Gap junction
Gap Junctions
Isolated Heart Preparation
medicine.disease
Voltage-Sensitive Dye Imaging
Coupling (electronics)
Disease Models, Animal
Cardiovascular System & Hematology
chemistry
Ventricular Fibrillation
Ventricular fibrillation
Cardiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 17553245 and 00086363
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Research
- Accession number :
- edsair.doi.dedup.....59822e0177343fca5098091cb7cc4ac6