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Erythropoietin Enhances Neovascularization of Ischemic Myocardium and Improves Left Ventricular Dysfunction After Myocardial Infarction in Dogs

Authors :
Masatsugu Hori
Hiroshi Asanuma
Masakatsu Wakeno
Yoshiro Shinozaki
Masafumi Myoishi
Kazuo Komamura
Tetsuo Minamino
Osamu Tsukamoto
Masashi Fujita
Seiji Takashima
Ken-ichiro Okada
Hidekazu Koyama
Masamichi Shiraga
Hidezo Mori
Masafumi Kitakaze
Akio Hirata
Source :
Journal of the American College of Cardiology. 48(1):176-184
Publication Year :
2006
Publisher :
Elsevier BV, 2006.

Abstract

Objectives We investigated the effects of erythropoietin (EPO) on neovascularization and cardiac function after myocardial infarction (MI). Background Erythropoietin exerts antiapoptotic effects and mobilizes endothelial progenitor cells (EPCs). Methods We intravenously administered EPO (1,000 IU/kg) immediately [EPO(0) group], 6 h [EPO(6h) group], or 1 week [EPO(1wk) group] after the permanent ligation of the coronary artery in dogs. Control animals received saline immediately after the ligation. Results The infarct size 6 h after MI was significantly smaller in the EPO(0) group than in the control group (61.5 ± 6.0% vs. 22.9 ± 2.2%). One week after MI, the circulating CD34-positive mononuclear cell numbers in both the EPO(0) and the EPO(6h) groups were significantly higher than in the control group. In the ischemic region, the capillary density and myocardial blood flow 4 weeks after MI was significantly higher in both the EPO(0) and the EPO(6h) groups than in the control group. Four weeks after MI, left ventricular (LV) ejection fraction in the EPO(6h) (48.6 ± 1.9%) group was significantly higher than that in either the control (41.9 ± 0.9%) or the EPO(1wk) (42.6 ± 1.2%) group but significantly lower than that in the EPO(0) group (56.1 ± 2.3%). The LV end-diastolic pressure 4 weeks after MI in both the EPO(0) and the EPO(6h) groups was significantly lower than either the control or the EPO(1wk) group. Hematologic parameters did not differ among the groups. Conclusions In addition to its acute infarct size-limiting effect, EPO enhances neovascularization, likely via EPC mobilization, and improves cardiac dysfunction in the chronic phase, although it has time-window limitations.

Details

ISSN :
07351097
Volume :
48
Issue :
1
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology
Accession number :
edsair.doi.dedup.....597e39173fda9281c9eb96e4a1066041
Full Text :
https://doi.org/10.1016/j.jacc.2006.04.008