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Presession noise increases sensitivity to chlordiazepoxide's discriminative stimulus in pigeons
- Source :
- Progress in neuro-psychopharmacologybiological psychiatry. 21(7)
- Publication Year :
- 1998
-
Abstract
- 1. 1. Pigeons were trained to discriminate chlordiazepoxide (CDP) from saline using two-key food reinforced drug discrimination procedures. Discriminative control by CDP was maintained despite extended training with vehicle-like doses of CDP, by using a modified “fading” procedure that provided for a mixture of drug discrimination training sessions preceded by an i.m. injection of either 8.0 mg/kg CDP, or a lower training dose of CDP (4.0, 2.8, 2. 0, 1.4, 1.0, 0.7, or 0.5 mg/kg CDP), or saline. The lower training dose was decreased across blocks of sessions. 2. 2. Four lower training doses (1.4, 1.0, 0.7, and 0.5 mg/kg CDP) were retrained, with 10 min of 98 dB of noise administered 75 min prior to each drug discrimination training session. Presession exposure to noise increased percent CDP-appropriate choices for each of the four lower training doses by 15–20% over those obtained previously. 3. 3. It is concluded that brief presession exposure to loud noise increases sensitivity to the discriminative stimulus effects of low training doses of CDP.
- Subjects :
- Pharmacology
Benzodiazepine
Reinforcement Schedule
medicine.drug_class
medicine.medical_treatment
Chlordiazepoxide
carbohydrates (lipids)
Discrimination Learning
Noise
Anti-Anxiety Agents
Anesthesia
medicine
Animals
lipids (amino acids, peptides, and proteins)
Stimulus control
Psychology
Drug discrimination
Columbidae
Saline
Biological Psychiatry
Stress, Psychological
medicine.drug
Subjects
Details
- ISSN :
- 02785846
- Volume :
- 21
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Progress in neuro-psychopharmacologybiological psychiatry
- Accession number :
- edsair.doi.dedup.....597b677737e1e76852523915cc92bba2