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Human Apoptotic Cells, Generated by Extracorporeal Photopheresis, Modulate Allogeneic Immune Response
- Source :
- Frontiers in Immunology, Vol 10 (2019), Frontiers in Immunology, Frontiers in Immunology, Frontiers, 2019, 10, pp.2908. ⟨10.3389/fimmu.2019.02908⟩, Frontiers in Immunology, 2019, 10, pp.2908. ⟨10.3389/fimmu.2019.02908⟩
- Publication Year :
- 2019
- Publisher :
- Frontiers Media SA, 2019.
-
Abstract
- International audience; The induction of specific and sustainable tolerance is a challenging issue in organ transplantation. The discovery of the immunosuppressive properties of apoptotic cells in animal models has paved the way for their use in human transplantation. In this work, we aimed to define a stable, reproducible, and clinically compatible production procedure of human apoptotic cells (Apo-cells). Using a clinically approved extracorporeal photopheresis technique, we have produced and characterized phenotypically and functionally human apoptotic cells. These Apo-cells have immunosuppressive properties proved in vitro and in vivo in NOD/SCID/γC mice by their capacity to modulate an allogeneic response following both a direct and an indirect antigen presentation. These results brought the rationale for the use of Apo-cells in tolerance induction protocol for organ transplantation.
- Subjects :
- 0301 basic medicine
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty
Antigen presentation
apoptotic cell
Immunology
Apoptosis
Mice, SCID
Nod
immunomodulation
Organ transplantation
Mice
03 medical and health sciences
0302 clinical medicine
Immune system
Mice, Inbred NOD
In vivo
NSG mice
Extracorporeal Photopheresis
Immune Tolerance
medicine
Animals
Humans
Immunology and Allergy
Original Research
Antigen Presentation
tolerance
business.industry
[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy
Transplantation
Tolerance induction
030104 developmental biology
Photopheresis
Cancer research
[SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy
business
lcsh:RC581-607
030215 immunology
transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....594c3c97df4f97d7b76e86a90ab0b641
- Full Text :
- https://doi.org/10.3389/fimmu.2019.02908