Back to Search
Start Over
IMMUNOLOGIC AGING IN ADULTS WITH CONGENITAL HEART DISEASE: DOES INFANT STERNOTOMY MATTER?
- Source :
- Journal of the American College of Cardiology. 63(12)
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Thymectomy is performed routinely in infants undergoing cardiothoracic surgery. Children post-sternotomy have decreased numbers of T lymphocytes, although the mechanisms involved and long-term consequences of this have not been defined. We hypothesized that lymphopenia in patients with adult congenital heart disease (ACHD) would be reflective of premature T cell maturation and exhaustion. Adults with ACHD who had sternotomy to repair congenital heart disease as infants (
- Subjects :
- Senescence
Adult
Heart Defects, Congenital
Male
Pediatrics
medicine.medical_specialty
Aging
Heart disease
T cell
medicine.medical_treatment
Lymphocyte
Pilot Projects
Gastroenterology
Article
Young Adult
Immune system
Internal medicine
medicine
Cytotoxic T cell
Humans
Prospective Studies
business.industry
Infant, Newborn
Infant
medicine.disease
Flow Cytometry
Thymectomy
Sternotomy
Surgery
Cardiac surgery
CD4 Lymphocyte Count
medicine.anatomical_structure
Cardiothoracic surgery
Case-Control Studies
Pediatrics, Perinatology and Child Health
Female
business
Cardiology and Cardiovascular Medicine
CD8
Biomarkers
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 63
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....5945616272f188b937578388641f0b5f
- Full Text :
- https://doi.org/10.1016/s0735-1097(14)60488-5