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Activation and Migration of Adventitial Fibroblasts Contributes to Vascular Remodeling
- Source :
- The Anatomical Record. 301:1216-1223
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- The rat carotid artery balloon injury model was used to prove the activation and migration of adventitial fibroblasts. We found that at day 7 after injury, adventitial fibroblasts proliferated, transformed into myofibroblasts under transmission electron microscopy in the model group. Simultaneously, we proved that the adventitial cells migrated to the media and intima on seventh day after injury by directly labeled the adventitial cells by the in vivo gene transfer technique. Moreover, we captured the precise moment when the adventitial fibroblasts migrated from the adventitia to the media through the external elastic plate under transmission electron microscope. This study provides direct evidences that adventitial fibroblasts activate and migrate to the media and intima, then actively take part in revascularization. Anat Rec, 301:1216-1223, 2018. © 2018 Wiley Periodicals, Inc.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Histology
Chemistry
Carotid arteries
medicine.medical_treatment
030204 cardiovascular system & hematology
Revascularization
Balloon injury
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Gene Transfer Technique
In vivo
Adventitia
medicine
Anatomy
Myofibroblast
Ecology, Evolution, Behavior and Systematics
Biotechnology
Subjects
Details
- ISSN :
- 19328494 and 19328486
- Volume :
- 301
- Database :
- OpenAIRE
- Journal :
- The Anatomical Record
- Accession number :
- edsair.doi.dedup.....5938db7d6c8f25cd89342629a66755e2