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Mus spretus SEG/Pas mice resist virulent Yersinia pestis, under multigenic control
- Source :
- Genes and Immunity, Genes and Immunity, 2011, 12 (1), pp.23-30. ⟨10.1038/gene.2010.45⟩, Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2011, 12 (1), pp.23-30. ⟨10.1038/gene.2010.45⟩
- Publication Year :
- 2011
- Publisher :
- HAL CCSD, 2011.
-
Abstract
- International audience; Laboratory mice are well known to be highly susceptible to virulent strains of Yersinia pestis in experimental models of bubonic plague. We have found that Mus spretus-derived SEG/Pas (SEG) mice are exceptionally resistant to virulent CO92 and 6/69 wild type strains. Upon subcutaneous injection of 10(2) colony-forming units (CFU), 90% of females and 68% of males survived, compared with only an 8% survival rate for both male and female C57BL/6 mice. Furthermore, half of the SEG mice survived a challenge of up to 10(7) CFU. The time required for mortality was similar between B6 and SEG, suggesting that survival is dependent on early rather than late processes. The analysis of 322 backcross mice identified three significant quantitative trait loci (QTLs) on chromosomes 3, 4 and 6, with dominant SEG protective alleles. Each QTL increased the survival rate by approximately 20%. The three QTLs function additively, thereby accounting for 67% of the difference between the parental phenotypes. Mice heterozygous for the three QTLs were just as resistant as SEG mice to Y. pestis challenge. The SEG strain therefore offers an invaluable opportunity to unravel mechanisms and underlying genetic factors of resistance against Y. pestis infection.
- Subjects :
- Male
Yersinia pestis
Mus spretus
Quantitative Trait Loci
Immunology
MESH: Yersinia pestis
Virulence
Quantitative trait locus
Mice
03 medical and health sciences
Species Specificity
Genetics
Animals
MESH: Species Specificity
MESH: Animals
Allele
MESH: Mice
Genetics (clinical)
030304 developmental biology
0303 health sciences
[SDV.GEN]Life Sciences [q-bio]/Genetics
biology
030306 microbiology
Wild type
biology.organism_classification
Phenotype
Immunity, Innate
MESH: Male
MESH: Quantitative Trait Loci
3. Good health
Backcrossing
Female
MESH: Immunity, Innate
MESH: Female
Subjects
Details
- Language :
- English
- ISSN :
- 14664879 and 14765470
- Database :
- OpenAIRE
- Journal :
- Genes and Immunity, Genes and Immunity, 2011, 12 (1), pp.23-30. ⟨10.1038/gene.2010.45⟩, Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2011, 12 (1), pp.23-30. ⟨10.1038/gene.2010.45⟩
- Accession number :
- edsair.doi.dedup.....593352fe13ab656ebf8007d06e65435e