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Extrapyramidal symptoms during treatment of first schizophrenia episode: Results from EUFEST
- Source :
- European Neuropsychopharmacology. 24:1500-1505
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- The European First Episode Schizophrenia Trial (EUFEST) included first-episode schizophrenia patients, assessing the efficacy of five antipsychotic drugs (haloperidol, amisulpride, olanzapine, quetiapine and ziprasidone) over one year. Baseline frequency of extrapyramidal symptoms (EPS) in this group of patients (n=490) was as follows: parkinsonism 10.8%, akathisia 10.0%, dystonia 1.8%, and dyskinesia 0.6%. The frequency of parkinsonism at baseline was greater in patients with a brief prior exposure to antipsychotics (≤2 weeks) compared with antipsychotic-naïve ones, and was positively correlated with the intensity of negative symptoms and negatively with depressive symptoms. After one month of treatment, the increase of parkinsonism was highest in patients receiving haloperidol (+13%), that of akathisia in patients treated with ziprasidone (+14%), and 10.1% of the patients were taking anticholinergic drugs, most frequently in the haloperidol group (24%). In 291 patients remaining on treatment after one year, both parkinsonism and akathisia had decreased: the frequency of parkinsonism was 3%, highest in the haloperidol group (9.1%), that of akathisia was 3%, highest in the quetiapine group (7.5%), and 4% of patients were taking anticholinergic drugs, most frequently those receiving haloperidol (10.5%). The results obtained suggest that in first-episode schizophrenia patients during the first year of antipsychotic treatment (in this case amisulpride, haloperidol in low doses, olanzapine, quetiapine and ziprasidone), EPS were present as manageable clinical problems.
- Subjects :
- Adult
Male
Olanzapine
medicine.medical_specialty
medicine.medical_treatment
Akathisia
Young Adult
Basal Ganglia Diseases
Extrapyramidal symptoms
Internal medicine
medicine
Haloperidol
Humans
Pharmacology (medical)
Ziprasidone
Amisulpride
Antipsychotic
Biological Psychiatry
Psychiatric Status Rating Scales
Pharmacology
Depression
business.industry
Europe
Psychiatry and Mental health
Treatment Outcome
Neurology
Anesthesia
Quality of Life
Schizophrenia
Quetiapine
Female
Neurology (clinical)
medicine.symptom
business
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 0924977X
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- European Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....59307f79e5070548ba435f5ad245663f