Back to Search
Start Over
Intranasal treatment of lixisenatide attenuated emotional and olfactory symptoms via CREB-mediated adult neurogenesis in mouse depression model
- Source :
- Aging (Albany NY)
- Publication Year :
- 2021
- Publisher :
- Impact Journals, LLC, 2021.
-
Abstract
- Convergent lines of evidence indicate a striking correlation between olfactory deficits and depressive symptoms. However, the effectiveness of intranasal treatment of antidepressant or other neurotrophic agents remains poorly understanding. Here in this study, we created depression mouse model and explored the antidepressant effects of GLP-1 analog lixisenatide (LXT) with intranasal treatment. Consecutive intranasal treatment of LXT remarkably reduced the depressive and anxiety behaviors. Meanwhile, it also improved the olfactory memory and olfactory sensitivity. Immunofluorescent analysis demonstrated the LXT improved the adult neurogenesis in olfactory system and hippocampus. Inhibition of adult neurogenesis with TMZ caused the compromised effects of LXT in improving emotional and olfactory functions, suggesting the vital role of adult neurogenesis in LXT induced depression therapeutic effects. Treatment of LXT resulted in the increased phosphorylation of CREB protein in hippocampal tissue, indicating CREB plays important roles in antidepressant effects of LXT intranasal treatment. Inhibiting CREB with chemical approach decreased effects of LXT in reserving depression induced emotional and olfactory functions. In conclusion, our study suggests intranasal treatment of LXT could be a potential antidepressant to improve the olfactory functions as well as the emotional behaviors.
- Subjects :
- Olfactory system
Aging
Neurogenesis
Hippocampus
Pharmacology
Hippocampal formation
CREB
Glucagon-Like Peptide-1 Receptor
Elevated Plus Maze Test
Mice
Olfaction Disorders
Lixisenatide
chemistry.chemical_compound
Animals
Medicine
Olfactory memory
Cyclic AMP Response Element-Binding Protein
Administration, Intranasal
Depressive Disorder
Behavior, Animal
biology
Depression
business.industry
olfactory function
Cell Biology
Olfactory Bulb
Disease Models, Animal
Hindlimb Suspension
chemistry
biology.protein
Antidepressant
Peptides
business
lixisenatide
Open Field Test
Stress, Psychological
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....5925aed387a757b8f14aa30b44360eac