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The peopling of Korea revealed by analyses of mitochondrial DNA and Y-chromosomal markers
- Source :
- PLoS ONE, Vol 4, Iss 1, p e4210 (2009), PLoS ONE
- Publication Year :
- 2009
- Publisher :
- Public Library of Science (PLoS), 2009.
-
Abstract
- Background The Koreans are generally considered a northeast Asian group because of their geographical location. However, recent findings from Y chromosome studies showed that the Korean population contains lineages from both southern and northern parts of East Asia. To understand the genetic history and relationships of Korea more fully, additional data and analyses are necessary. Methodology and Results We analyzed mitochondrial DNA (mtDNA) sequence variation in the hypervariable segments I and II (HVS-I and HVS-II) and haplogroup-specific mutations in coding regions in 445 individuals from seven east Asian populations (Korean, Korean-Chinese, Mongolian, Manchurian, Han (Beijing), Vietnamese and Thais). In addition, published mtDNA haplogroup data (N = 3307), mtDNA HVS-I sequences (N = 2313), Y chromosome haplogroup data (N = 1697) and Y chromosome STR data (N = 2713) were analyzed to elucidate the genetic structure of East Asian populations. All the mtDNA profiles studied here were classified into subsets of haplogroups common in East Asia, with just two exceptions. In general, the Korean mtDNA profiles revealed similarities to other northeastern Asian populations through analysis of individual haplogroup distributions, genetic distances between populations or an analysis of molecular variance, although a minor southern contribution was also suggested. Reanalysis of Y-chromosomal data confirmed both the overall similarity to other northeastern populations, and also a larger paternal contribution from southeastern populations. Conclusion The present work provides evidence that peopling of Korea can be seen as a complex process, interpreted as an early northern Asian settlement with at least one subsequent male-biased southern-to-northern migration, possibly associated with the spread of rice agriculture.
- Subjects :
- Genetic Markers
Male
Mitochondrial DNA
Population
Population genetics
lcsh:Medicine
Biology
Y chromosome
DNA, Mitochondrial
Haplogroup
03 medical and health sciences
0302 clinical medicine
Humans
East Asia
030216 legal & forensic medicine
education
Evolutionary Biology/Genomics
lcsh:Science
030304 developmental biology
Genetics
0303 health sciences
education.field_of_study
Multidisciplinary
Chromosomes, Human, Y
Korea
lcsh:R
Emigration and Immigration
Genetics and Genomics/Bioinformatics
Evolutionary Biology/Human Evolution
Phylogeography
Genetics, Population
Genetic marker
lcsh:Q
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 4
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....59216dceafaebfa950532c1e7e05d20c