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Potential of curcumin-loaded cubosomes for topical treatment of cervical cancer

Authors :
Francesca Damiani Victorelli
Livia Salvati Manni
Stefania Biffi
Barbara Bortot
Hilde Harb Buzzá
Viviane Lutz-Bueno
Stephan Handschin
Giovana Calixto
Sergio Murgia
Marlus Chorilli
Raffaele Mezzenga
Source :
Journal of Colloid and Interface Science, 620, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Cervical cancer is one of the most common cancers affecting women worldwide. There are an estimated 570.000 new cases of cervical cancer each year and conventional treatments can cause severe side effects. In this work, we developed a platform for vaginal administration of lipophilic drugs for cervical cancer treatment. We formulated mucoadhesive cubosomes for the delivery of curcumin, a lipophilic drug for cervical cancer treatment, to increase its bioavailability and local absorption. This study tests the use of cubosomes for vaginal drug administration and assesses their potential efficiency using the CAM (chick embryo chorioallantoic membrane) model. SAXS (small-angle X-ray scattering), cryo-TEM (cryo-transmission electron microscopy), and dynamic light scattering (DLS) were employed to characterise the system. With ex vivo permeation and retention studies, we find that the curcumin released from our system is retained in the vaginal mucosa. In vitro cytotoxicity assay and cellular uptake showed an increased cytotoxic effect of curcumin against HeLa cell line when incorporated into the cubosomes. The curcumin-loaded cubosomes also demonstrated an antiangiogenic effect evaluated in vivo by the CAM model.<br />Journal of Colloid and Interface Science, 620<br />ISSN:0021-9797<br />ISSN:1095-7103

Details

Language :
English
ISSN :
00219797 and 10957103
Database :
OpenAIRE
Journal :
Journal of Colloid and Interface Science, 620, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
Accession number :
edsair.doi.dedup.....5918d0f824c60c4e537ce8c830425c72