Supplementary Figures S1-S5 from Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation

TGFβR inhibition suppresses mesenchymal features in human HCC cell lines (S1); AXIN2 and GLI are induced by Wnt and SHH signals in the epithelial-to-mesenchymal transition network model (S2); All stable motifs (feedback loops) stabilizing the TGFβ-driven EMT phenotype (S3); The ratio between the timescale of the slow and fast processes does not matter as long as it is significantly larger than one (S4); Exploration of alternative rules to describe nuclear localization of β-catenin (S5).