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Mycobacterium fortuitum-chelonae complex infection in a child with complete interleukin-12 receptor beta 1 deficiency
- Source :
- The Pediatric infectious disease journal. 20(5)
- Publication Year :
- 2001
-
Abstract
- A 10-year-old boy had chronic diarrhea, abdominal pain, severe weight loss and hepatomegaly; multiple enlarged para-aortic and mesenteric lymph nodes. Mycobacterium fortuitum-chelonae complex was identified in the culture of the lymph nodes. Interleukin-12 receptor beta 1 expression could not be observed in phytohemagglutinin-driven T cell blasts. A homozygous missense interleukin-12 receptor beta 1 mutation was found (R173P).
- Subjects :
- Microbiology (medical)
Male
T cell
Mycobacterium Infections, Nontuberculous
Beta-1 adrenergic receptor
medicine
Missense mutation
Mesenteric lymph nodes
Humans
Child
Interleukin 12 receptor, beta 1 subunit
biology
business.industry
Mycobacterium fortuitum
Receptors, Interleukin-12
Receptors, Interleukin
biology.organism_classification
Flow Cytometry
Infectious Diseases
medicine.anatomical_structure
Pediatrics, Perinatology and Child Health
Immunology
Mutation
Interleukin 12
Lymph
Lymph Nodes
business
Subjects
Details
- ISSN :
- 08913668
- Volume :
- 20
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Pediatric infectious disease journal
- Accession number :
- edsair.doi.dedup.....5908ca835e8894118eefb21a0e622c03