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Prevention of deep vein thrombosis in patients with hip fractures: low molecular weight heparin versus dextran
- Source :
- World journal of surgery. 16(5)
- Publication Year :
- 1992
-
Abstract
- A randomized open trial was undertaken to compare the antithrombotic efficacy of a low molecular weight heparin (LMWH; Sandoparin) with that of dextran 70 in patients undergoing surgery for hip fracture. One hundred thirteen patients received LMWH once daily subcutaneously at a fixed dosage while 103 patients received intravenous dextran 70. Postoperative deep vein thrombosis (DVT) was assessed by a diagnostic algorithm using the 125Iodine fibrinogen uptake test as screening and Duplex ultrasonography and/or ascending venography as confirming techniques for suspected DVT. The frequency of DVT was significantly lower in the LMWH group than in the dextran group (15.5 versus 32.6%, p less than 0.005). Proximal DVT was rare in both groups (LMWH: 2%, Dextran: 1%). Only one case of fatal fat pulmonary embolism was observed during the 10 day prophylaxis period in a patient receiving Dextran. Three cases of pulmonary embolism occurred later; one fatal event in the dextran group on day 14, and two cases in the LMWH group (one fatal and one non-fatal event) on day 14 and 17, respectively. There was no major bleeding complication in either group. We conclude that the LMWH we used is safe, was well tolerated, and has a significantly better thromboprophylactic effect than dextran 70.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
Deep vein
Venography
Low molecular weight heparin
Fibrinogen uptake test
Postoperative Complications
medicine
Humans
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Hip Fractures
Anticoagulant
Dextrans
Heparin, Low-Molecular-Weight
Middle Aged
Thrombophlebitis
medicine.disease
Thrombosis
Surgery
Dextran 70
Pulmonary embolism
medicine.anatomical_structure
Anesthesia
Female
business
Pulmonary Embolism
Subjects
Details
- ISSN :
- 03642313
- Volume :
- 16
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- World journal of surgery
- Accession number :
- edsair.doi.dedup.....5904bc28d38d96509bc0052644c7017f