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Glycemic parameters with multiple daily injections using insulin glargine versus insulin pump
- Source :
- Diabetes technologytherapeutics. 6(1)
- Publication Year :
- 2004
-
Abstract
- This study compared external insulin pump treatment using insulin lispro or insulin aspart with multiple daily injections (MDI; four or more injections per day) using insulin glargine and insulin lispro or insulin aspart. An electronic database was used to retrieve various parameters of glycemic control for 515 adult patients with type 1 diabetes. An insulin pump was used by 216 patients, and 299 patients were taking insulin glargine for at least 6 months. The mean age (approximately 33 years), duration of diabetes (approximately 16 years), and duration of treatment (approximately 12 months) were similar for both the pump and insulin glargine groups. The mean (+/-SEM) A1C values were significantly reduced in both groups from the baseline to the end of the study (7.7 +/- 0.1% to 7.5 +/- 0.1% for the pump group and 8.0 +/- 0.1% to 7.7 +/- 0.1% for the insulin glargine group, P0.001) with similar weight gain (P0.05) in both groups. The insulin glargine group significantly reduced basal insulin intake at follow-up. The premeal boluses were similar throughout the study for both groups. The subjects reporting severe hypoglycemic episodes were similar in the two groups; however, there were 12 cases of diabetic ketoacidosis reported in the pump group and none in the insulin glargine group. Patients with type 1 diabetes can achieve similar glycemic control using insulin glargine with premeal insulin lispro or by using an external infusion pump with insulin lispro or insulin aspart. However, costs and episodes of diabetic ketoacidosis are significantly higher for insulin pump users.
- Subjects :
- Insulin pump
Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Injections, Subcutaneous
Insulin Glargine
Diabetic Ketoacidosis
Insulin aspart
Endocrinology
Insulin Infusion Systems
Internal medicine
Diabetes mellitus
medicine
Insulin lispro
Humans
Hypoglycemic Agents
Insulin
Insulin Aspart
Glycemic
Retrospective Studies
Glycated Hemoglobin
Type 1 diabetes
Insulin Lispro
business.industry
Insulin glargine
Body Weight
Infusion Pumps, Implantable
medicine.disease
Insulin, Long-Acting
Medical Laboratory Technology
Diabetes Mellitus, Type 1
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 15209156
- Volume :
- 6
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diabetes technologytherapeutics
- Accession number :
- edsair.doi.dedup.....59019a0ee44a95dc2c7e703b0bb09a3b