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Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat

Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat

Authors :
Renáta Szabó
Rudolf Gesztelyi
Andrea Kurucz
Anikó Pósa
Adrienn Mónika Szabó
Dániel Priksz
Adam Kemeny-Beke
Balázs Varga
Judit Remenyik
Mariann Bombicz
Nora Lampe
Bela Juhasz
Source :
Molecules, Vol 22, Iss 10, p 1782 (2017), Molecules; Volume 22; Issue 10; Pages: 1782, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Publication Year :
2017
Publisher :
MDPI AG, 2017.

Abstract

Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation.

Details

ISSN :
14203049
Volume :
22
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....58fdb857221476aa960c85537bc2288b
Full Text :
https://doi.org/10.3390/molecules22101782