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Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat
Protective Effect of Prunus Cerasus (Sour Cherry) Seed Extract on the Recovery of Ischemia/Reperfusion-Induced Retinal Damage in Zucker Diabetic Fatty Rat
- Source :
- Molecules, Vol 22, Iss 10, p 1782 (2017), Molecules; Volume 22; Issue 10; Pages: 1782, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation.
- Subjects :
- Blood Glucose
sour cherry
0301 basic medicine
retina
Prunus cerasus
ischemia-reperfusion
electroretinography
ZDF rat
Pharmaceutical Science
Pharmacology
Analytical Chemistry
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
medicine.diagnostic_test
biology
Orvostudományok
Diabetic retinopathy
medicine.anatomical_structure
Chemistry (miscellaneous)
Reperfusion Injury
Seeds
Molecular Medicine
Erg
medicine.medical_specialty
Ischemia
Prunus avium
Article
Diabetes Mellitus, Experimental
lcsh:QD241-441
03 medical and health sciences
lcsh:Organic chemistry
Diabetes mellitus
medicine
Animals
Humans
Physical and Theoretical Chemistry
Retina
Diabetic Retinopathy
Plant Extracts
business.industry
Gyógyszerészeti tudományok
Organic Chemistry
Retinal
medicine.disease
biology.organism_classification
Rats
Rats, Zucker
Surgery
030104 developmental biology
chemistry
030221 ophthalmology & optometry
business
Heme Oxygenase-1
Electroretinography
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....58fdb857221476aa960c85537bc2288b
- Full Text :
- https://doi.org/10.3390/molecules22101782