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Biometrics, Impact, and Significance of Basal Linear Deposit and Subretinal Drusenoid Deposit in Age-Related Macular Degeneration
- Source :
- Investigative Ophthalmology & Visual Science, Investigative ophthalmology & visual science, vol 62, iss 1
- Publication Year :
- 2021
- Publisher :
- The Association for Research in Vision and Ophthalmology, 2021.
-
Abstract
- Purpose Basal linear deposit (BLinD) is a thin layer of soft drusen material. To elucidate the biology of extracellular deposits conferring age-related macular degeneration (AMD) progression risk and inform multimodal clinical imaging based on optical coherence tomography (OCT), we examined lipid content and regional prevalence of BLinD, soft drusen, pre-BLinD, and subretinal drusenoid deposit (SDD) in AMD and non-AMD aged eyes. We estimated BLinD volume and illustrated its relation to type 1 macular neovascularization (MNV). Methods Donor eyes were classified as early to intermediate AMD (n = 25) and age-matched controls (n = 54). In high-resolution histology, we assessed BLinD/soft drusen thickness at 836 and 1716 locations in AMD and control eyes, respectively. BLinD volume was estimated using solid geometry in donor eyes, one clinically characterized. Results BLinD, drusen, type 1 MNV, and fluid occupy the sub-RPE-basal laminar space. BLinD volume in a 3-mm diameter circle may be as much as 0.0315 mm3. Osmophilic lipid was more concentrated in BLinD/drusen than SDD. In the fovea, BLinD/drusen was prevalent in AMD eyes; pre-BLinD was prevalent in control eyes. SDD was low in the fovea and high in perifovea, especially in AMD eyes. Conclusions Although invisible, BLinD may presage type 1 MNV. BLinD volume approaches the criterion OCT drusen volume of 0.03 mm3 for AMD progression risk. BLinD culminates years of subfoveal lipid accumulation. SDD is detected relatively late in life, with currently unknown precursors. Deposit topography suggests one outer retinal lipid recycling system serving specialized cone and rod physiology, and its dysregulation in AMD is due to impaired transfer to the circulation.
- Subjects :
- Male
medicine.medical_specialty
Lipid accumulation
Biometry
genetic structures
Retinal Drusen
Retinal Pigment Epithelium
Drusen
Ophthalmology & Optometry
Medical and Health Sciences
Retina
Basement Membrane
histology
chemistry.chemical_compound
Basal (phylogenetics)
Macular Degeneration
subretinal drusenoid deposit
Optical coherence tomography
Age related
Ophthalmology
Perifovea
medicine
Humans
basal linear deposit
age-related macular degeneration
Aged
Retrospective Studies
Aged, 80 and over
optical coherence tomography
medicine.diagnostic_test
business.industry
drusen
Retinal
photoreceptors
Macular degeneration
Biological Sciences
Middle Aged
medicine.disease
eye diseases
Tissue Donors
chemistry
histopathology
Female
sense organs
neovascularization
business
clinicopathologic correlation
Tomography, Optical Coherence
Subjects
Details
- Language :
- English
- ISSN :
- 15525783 and 01460404
- Volume :
- 62
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Investigative Ophthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....58f86a887634b1662f7fc2bfddb0b93e