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Fine-scale analysis of 16S rRNA sequences reveals a high level of taxonomic diversity among vaginal Atopobium spp
- Source :
- Pathogens and Disease. 73
- Publication Year :
- 2015
- Publisher :
- Oxford University Press (OUP), 2015.
-
Abstract
- Although vaginal microbial communities of some healthy women have high proportions of Atopobium vaginae, the genus Atopobium is more commonly associated with bacterial vaginosis, a syndrome associated with an increased risk of adverse pregnancy outcomes and the transmission of sexually transmitted diseases. Genetic differences within Atopobium species may explain why single species can be associated with both health and disease. We used 16S rRNA gene sequences from previously published studies to explore the taxonomic diversity of the genus Atopobium in vaginal microbial communities of healthy women. Although A. vaginae was the species most commonly found, we also observed three other Atopobium species in the vaginal microbiota, one of which, A. parvulum, was not previously known to reside in the human vagina. Furthermore, we found several potential novel species of the genus Atopobium and multiple phylogenetic clades of A. vaginae. The diversity of Atopobium found in our study, which focused only on samples from healthy women, is greater than previously recognized, suggesting that analysis of samples from women with BV would yield even more diversity. Classification of microbes only to the genus level may thus obfuscate differences that might be important to better understand health or disease.
- Subjects :
- DNA, Bacterial
Microbiology (medical)
Atopobium
Zoology
Atopobium vaginae
Biology
DNA, Ribosomal
Genus
RNA, Ribosomal, 16S
medicine
Humans
Immunology and Allergy
Clade
Genetic diversity
General Immunology and Microbiology
Phylogenetic tree
Ecology
Computational Biology
Genetic Variation
Sequence Analysis, DNA
General Medicine
biology.organism_classification
medicine.disease
16S ribosomal RNA
Healthy Volunteers
Actinobacteria
Infectious Diseases
Vagina
Female
Bacterial vaginosis
Research Article
Subjects
Details
- ISSN :
- 2049632X
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Pathogens and Disease
- Accession number :
- edsair.doi.dedup.....58f69ae1ac08024c6a6e132911404de6