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Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study

Authors :
Meng-Xia Zhang
Ting Liu
Rui You
Xiong Zou
Yong-Long Liu
Xi Ding
Chong-Yang Duan
Han-Shi Xu
You-Ping Liu
Rou Jiang
Zhi-Qiang Wang
Chao Lin
Yu-Long Xie
Si-Yuan Chen
Yan-Feng Ouyang
Ruo-Qi Xie
Yi-Jun Hua
Rui Sun
Pei-Yu Huang
Shun-Lan Wang
Ming-Yuan Chen
Source :
Therapeutic Advances in Medical Oncology. 14:175883592211124
Publication Year :
2022
Publisher :
SAGE Publications, 2022.

Abstract

Background: Studies of local therapy (LT) to metastatic foci from nasopharyngeal carcinoma (NPC) are inconsistent and controversial. Here, we aimed to explore the survival benefit of LT directed at metastatic foci from NPC. Methods: A retrospective analysis was conducted in NPC patients with liver, lung, and/or bone metastases. The postmetastatic overall survival (OS) rate was analyzed using the Kaplan–Meier method and compared by the log-rank test. Multivariate analysis was performed using the Cox hazard model. Subgroup analyses evaluating the effect of LT were performed for prespecified covariates. Propensity score matching was applied to homogenize the compared arms. Results: Overall, 2041 of 2962 patients were eligible for analysis. At a median follow-up of 43.4 months, the 5-year OS improved by an absolute difference of 14.6%, from 46.2% in the LT group versus 31.6% in the non-LT group, which led to a hazard ratio of 0.634 for death ( p 60 Gy was found to yield more survival benefit than that of BED ⩽ 60 Gy. Conclusions: The addition of LT directed at metastasis has demonstrated an improvement to OS compared with non-LT group in the present matched-pair study, especially for patients with liver and/or lung metastases.

Subjects

Subjects :
Oncology

Details

ISSN :
17588359
Volume :
14
Database :
OpenAIRE
Journal :
Therapeutic Advances in Medical Oncology
Accession number :
edsair.doi.dedup.....58f4e901d33931cfe3ad8d927aa2a31f
Full Text :
https://doi.org/10.1177/17588359221112486