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Use of histologic margin evaluation to predict recurrence of cutaneous malignant tumors in dogs and cats after surgical excision
- Source :
- Journal of the American Veterinary Medical Association. 240(10)
- Publication Year :
- 2012
-
Abstract
- Objective—To assess the usefulness of histologic evaluation of surgical margins to predict local recurrence of cutaneous malignant tumors in dogs and cats treated by means of surgical excision. Design—Prospective case series. Animals—40 dogs and 20 cats. Procedures—60 surgically excised tumors (20 soft tissue sarcomas [STSs], 20 mast cell tumors [MCTs], and 20 carcinomas) were examined histologically. Margins were classified as clean, close, or infiltrated; histologic grade was assessed in STSs and MCTs. Recurrence rates and recurrence-free intervals (RFIs) during a 24-month follow-up period were recorded, and method accuracy was calculated. Results—Surgical margins were clean in 29 of 60 (48%) tumors, close in 11 (18%), and infiltrated in 20 (33%). Tumors recurred in 27 of 60 (45%) animals, with a mean ± SD RFI of 229 ± 173 days. Recurrence rates for animals that had tumors with infiltrated (16/20) or close (8/11) margins were significantly higher than recurrence rate for animals that had tumors with clean margins (3/29). Margin classification was a significant predictor of RFI. Accuracy of the method to predict recurrence was 94% for carcinomas, 87% for STSs, and 76% for MCTs. Conclusions and Clinical Relevance—Histologic assessment of margin status was useful for predicting local recurrence of cutaneous malignant tumors in dogs and cats treated by means of excision alone. Method accuracy varied among tumor types and grades. Recurrence times suggested postsurgical follow-up should continue for ≥ 2 years. Results were similar for animals with infiltrated and close tumor margins, and careful postsurgical management is recommended for both.
- Subjects :
- Male
medicine.medical_specialty
PROGNOSIS
Skin Neoplasms
Mast-Cell Sarcoma
Cat Diseases
Mast cell tumors
Disease-Free Survival
Neoplasm Recurrence
Dogs
Predictive Value of Tests
Histologic grade
DOG
medicine
Animals
Dog Diseases
Prospective Studies
RECURRENCE
Prospective cohort study
Neoplasm Staging
CATS
General Veterinary
business.industry
Carcinoma
Soft tissue
CAT
Sarcoma
ONCOLOGY
Surgery
Treatment Outcome
Predictive value of tests
Cats
Surgical excision
Female
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 1943569X
- Volume :
- 240
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of the American Veterinary Medical Association
- Accession number :
- edsair.doi.dedup.....58ea20b222c5e04a30ede422ec2fe1b0