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Sex differences in hearing: Probing the role of estrogen signaling
- Source :
- J Acoust Soc Am
- Publication Year :
- 2019
- Publisher :
- Acoustical Society of America (ASA), 2019.
-
Abstract
- Hearing loss is the most common form of sensory impairment in humans, with an anticipated rise in incidence as the result of recreational noise exposures. Hearing loss is also the second most common health issue afflicting military veterans. Currently, there are no approved therapeutics to treat sensorineural hearing loss in humans. While hearing loss affects both men and women, sexual dimorphism is documented with respect to peripheral and central auditory physiology, as well as susceptibility to age-related and noise-induced hearing loss. Physiological differences between the sexes are often hormone-driven, and an increasing body of literature demonstrates that the hormone estrogen and its related signaling pathways may in part, modulate the aforementioned differences in hearing. From a mechanistic perspective, understanding the underpinnings of the hormonal modulation of hearing may lead to the development of therapeutics for age related and noise induced hearing loss. Here the authors review a number of studies that range from human populations to animal models, which have begun to provide a framework for understanding the functional role of estrogen signaling in hearing, particularly in normal and aberrant peripheral auditory physiology.
- Subjects :
- Male
0301 basic medicine
Auditory perception
medicine.medical_specialty
Acoustics and Ultrasonics
medicine.drug_class
Hearing loss
Hearing Loss, Sensorineural
Deafness
Audiology
03 medical and health sciences
0302 clinical medicine
Hearing
Arts and Humanities (miscellaneous)
otorhinolaryngologic diseases
Humans
Medicine
Sex Characteristics
business.industry
Hearing Tests
Auditory Threshold
Estrogens
Psychological and Physiological Acoustics
medicine.disease
030104 developmental biology
Hearing Loss, Noise-Induced
Estrogen
Auditory Perception
Sensorineural hearing loss
medicine.symptom
Noise
business
Auditory Physiology
030217 neurology & neurosurgery
Noise-induced hearing loss
Hormone
Sex characteristics
Subjects
Details
- ISSN :
- 00014966
- Volume :
- 145
- Database :
- OpenAIRE
- Journal :
- The Journal of the Acoustical Society of America
- Accession number :
- edsair.doi.dedup.....58e95e3b1cc280f937d04193eee8dbe4