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A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes
- Source :
- Reproductive Medicine and Biology
- Publication Year :
- 2021
-
Abstract
- Background Although animal models of PCOS have been used in many studies, none of them can reproduce both the reproductive and metabolic phenotypes of PCOS. In addition, behavioral parameters have not been evaluated in PCOS animal models. Purpose We tried to produce an improved rat model of PCOS, and the reproductive, metabolic, and behavioral phenotypes of the model rats were evaluated. Methods Female rats were implanted with silicon tubes containing oil‐dissolved dihydrotestosterone (Oil‐DHT) as a new PCOS model. Their phenotypes were compared with those of conventional PCOS model rats (DHT), into which tubes containing crystalline DHT were implanted, and non‐DHT‐treated rats (control). Results Both the Oil‐DHT and DHT rats showed greater body weight gain, food intake, and fat depot weight than the control rats. Furthermore, these groups showed fewer estrous stages and increased numbers of cystic follicles. The DHT rats exhibited lower ovarian and uterine weights than the control rats, whereas no such changes were observed in the Oil‐DHT rats. The Oil‐DHT and DHT rats showed less locomotor activity in the light phase than the control rats. Conclusions Our proposed PCOS model reproduced both the reproductive and metabolic phenotypes of PCOS and may have potential for PCOS research.
- Subjects :
- Genetics
Behavioral phenotypes
endocrine system
endocrine system diseases
DHT
urogenital system
media_common.quotation_subject
activity
Rat model
Cell Biology
Original Articles
Biology
female genital diseases and pregnancy complications
reproduction
Reproductive Medicine
metabolic
PCOS
Original Article
Reproduction
hormones, hormone substitutes, and hormone antagonists
media_common
Subjects
Details
- ISSN :
- 14455781
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Reproductive medicine and biology
- Accession number :
- edsair.doi.dedup.....58e90aff90a6ac92520ed7b41f3232f4