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Bidirectional variability in motor cortex excitability modulation following 1 mA transcranial direct current stimulation in healthy participants
- Source :
- Physiological Reports
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Due to the high interindividual response variability following transcranial direct current stimulation (tDCS), it is apparent that further research of the long‐lasting effects of the stimulation technique is required. We aimed to investigate interindividual variability following anodal tDCS and cathodal tDCS in a large‐scale prospective cross‐over study. Motor cortex physiology measurements were obtained using transcranial magnetic stimulation (TMS) in 59 healthy participants comparing motor‐evoked potential (MEP) magnitudes following two tDCS paradigms: 1 mA anodal tDCS for 13 min and 1 mA cathodal tDCS for 9 min. Analysis compared MEP changes over time for both polarities. Additionally, we applied hierarchical cluster analysis to assess the dynamics of poststimulation changes. Overall, anodal tDCS resulted in a significant increase in corticospinal excitability lasting for 40 min poststimulation, whereas cathodal tDCS did not alter corticospinal excitability. Cluster analysis revealed for cathodal tDCS both a cluster showing significant stable MEP reduction and a second cluster displaying MEP increase over time. Two diametrical clusters were also found for anodal tDCS. Regardless of polarity, individuals with MEP increase following stimulation showed steeper cortical recruitment curves compared to the clusters with decreased MEP magnitudes. The observed findings confirm a bidirectional modulation of corticospinal excitability following 1 mA tDCS in separate subgroups and the relationship to cortical recruitment.
- Subjects :
- Central Nervous System
Adult
Male
Anodal tdcs
Physiology
medicine.medical_treatment
Stimulation
Transcranial Direct Current Stimulation
050105 experimental psychology
Young Adult
03 medical and health sciences
0302 clinical medicine
Neuronal Plasticity and Repair
Physiology (medical)
medicine
Cluster Analysis
Humans
0501 psychology and cognitive sciences
ddc:610
Motor‐cortical plasticity
Original Research
response variability
Transcranial direct-current stimulation
Stimulation technique
business.industry
05 social sciences
Motor Cortex
Evoked Potentials, Motor
Response Variability
Transcranial magnetic stimulation
medicine.anatomical_structure
Cortical Excitability
Female
business
Neuroscience
030217 neurology & neurosurgery
Motor Control
Motor cortex
Subjects
Details
- ISSN :
- 2051817X
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Physiological Reports
- Accession number :
- edsair.doi.dedup.....58e354032816506818e7bdcf3ee231d9