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The proportion of lycopene isomers in human plasma is modulated by lycopene isomer profile in the meal but not by lycopene preparation
- Source :
- British Journal of Nutrition, British Journal of Nutrition, Cambridge University Press (CUP), 2012, 107 (10), pp.1482-1488. ⟨10.1017/S0007114511004569⟩, British Journal of Nutrition 10 (107), 1482-1488. (2012)
- Publication Year :
- 2017
-
Abstract
- Dietary lycopene consists mostly of the (all-E) isomer. Upon absorption, (all-E) lycopene undergoes isomerisation into various (Z)-isomers. Because these isomers offer potentially better health benefits than the (all-E) isomer, the aim of the present study was to investigate if the profile of lycopene isomers in intestinal lipoproteins is affected by the profile of lycopene isomers in the meal and by the tomato preparation. Six postprandial, crossover tests were performed in healthy men. Three meals provided about 70 % of the lycopene as (Z)-isomers, either mainly as 5-(Z) or 13-(Z), or as a mixture of 9-(Z) and 13-(Z) lycopene, while three tomato preparations provided lycopene mainly as the (all-E) isomer. Consumption of the 5-(Z) lycopene-rich meal led to a high (60 %) proportion of this isomer in TAG-rich lipoproteins (TRL), indicating a good absorption and/or a low intestinal conversion of this isomer. By contrast, consumption of meals rich in 9-(Z) and 13-(Z) lycopene isomers resulted in a low level of these isomers but high amounts of the 5-(Z) and (all-E) isomers in TRL. This indicates that the 9-(Z) and 13-(Z) isomers were less absorbed or were converted into 5-(Z) and (all-E) isomers. Dietary (Z)-lycopene isomers were, therefore, differently isomerised and released in TRL during their intestinal absorption in men. Consuming the three meals rich in (all-E) lycopene resulted in similar proportions of lycopene isomers in TRL: 60 % (all-E), 20 % 5-(Z), 9 % 13-(Z), 2 % 9-(Z) and 9 % unidentified (Z)-isomers. These results show that the tomato preparation has no impact on the lycopene isomerisation occurring during absorption in humans.
- Subjects :
- Male
Food Handling
030309 nutrition & dietetics
LYCOPENE
Medicine (miscellaneous)
Medicinal chemistry
Antioxidants
Intestinal absorption
chemistry.chemical_compound
Solanum lycopersicum
ABSORPTION
Intestinal Mucosa
CAROTENOIDS
Carotenoid
ComputingMilieux_MISCELLANEOUS
chemistry.chemical_classification
0303 health sciences
Meal
lipoprotéine
Nutrition and Dietetics
Chemistry
santé humaine
04 agricultural and veterinary sciences
Postprandial Period
040401 food science
Lycopene
Postprandial
Alimentation et Nutrition
nutrition humaine
Isomerization
Adult
Absorption (pharmacology)
Lipoproteins
Biological Availability
Young Adult
03 medical and health sciences
0404 agricultural biotechnology
Isomerism
Humans
Food and Nutrition
ISOMERISATION
Triglycerides
ABSORPTION INTESTINALE
Plant Extracts
plasma sanguin
Diet
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition
Intestinal Absorption
Human plasma
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Subjects
Details
- Language :
- English
- ISSN :
- 00071145 and 14752662
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition, British Journal of Nutrition, Cambridge University Press (CUP), 2012, 107 (10), pp.1482-1488. ⟨10.1017/S0007114511004569⟩, British Journal of Nutrition 10 (107), 1482-1488. (2012)
- Accession number :
- edsair.doi.dedup.....58e32b19f3a49dab47d22923937258c2