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Partitioning of cancer therapeutics in nuclear condensates
- Source :
- Science, PMC
- Publication Year :
- 2020
-
Abstract
- Drug partitioning in nuclear condensates There is increasing interest in the function of phase-separated biomolecular condensates in cells because of their distinct properties and expanding roles in important biological processes. Klein et al. considered the fate of small-molecule therapeutics in the context of nuclear condensates (see the Perspective by Viny and Levine). They show that certain antineoplastic drugs have physicochemical properties that cause them to concentrate preferentially in condensates, both in vitro and in cancer cells. This property influences drug activity, and protein mutations that alter condensate formation can lead to drug resistance. Optimizing condensate partitioning may be valuable in developing improved therapeutics. Science , this issue p. 1386 ; see also p. 1314
- Subjects :
- chemistry.chemical_classification
Drug
Multidisciplinary
Chemistry
SARS-CoV-2
Biomolecule
media_common.quotation_subject
Cancer
COVID-19
Nucleocapsid Proteins
medicine.disease
Phosphoproteins
Small molecule
In vitro
Article
Disease therapy
Drug activity
medicine
Biophysics
Antineoplastic Drugs
Coronavirus Nucleocapsid Proteins
Humans
media_common
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Science, PMC
- Accession number :
- edsair.doi.dedup.....58dbfd9ca343e2e0aae160b9eb4e7eba