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The power and the promise of organoid models for cancer precision medicine with next-generation functional diagnostics and pharmaceutical exploitation
- Source :
- Translational Oncology, Vol 14, Iss 8, Pp 101126-(2021), Translational Oncology
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- As organ-specific three-dimensional cell clusters derived from cancer tissue or cancer-specific stem cells, cancer-derived organoids are organized in the same manner of the cell sorting and spatial lineage restriction in vivo, making them ideal for simulating the characteristics of cancer and the heterogeneity of cancer cells in vivo. Besides the applications as a new in vitro model to study the physiological characteristics of normal tissues and organs, organoids are also used for in vivo cancer cell characterization, anti-cancer drug screening, and precision medicine. However, organoid cultures are not without limitations, i.e., the lack of nerves, blood vessels, and immune cells. As a result, organoids could not fully replicate the characteristics of organs but partially simulate the disease process. This review attempts to provide insights into the organoid models for cancer precision medicine.<br />Graphical abstract Image, graphical abstract
- Subjects :
- Organoid
0301 basic medicine
Cancer Research
Cell
Review
Computational biology
Biology
03 medical and health sciences
0302 clinical medicine
In vitro model
In vivo
medicine
RC254-282
Cancer
Precision medicine
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cell sorting
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Drug screening
Oncology
030220 oncology & carcinogenesis
Cancer cell
Stem cell
Subjects
Details
- ISSN :
- 19365233
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Translational Oncology
- Accession number :
- edsair.doi.dedup.....58db25016f05c7c4ac0dace66c64ab1f